I have been on both Seroquel and Trazadone. Currently on Trazadone. Like you, I'm finding it doesn't work as well. I do know that Seroquel is very powerful. Of course, the doc will start you off with a small dose. If more is needed, then I'm sure the doc will adjust the scrip accordingly. I don't know how I reacted with this first dose. It might take some time. I can't remember my experience with it. But it is a very calming drug--can really knock folks out!