I have pernicious anemia & take high doses (2000 mcq) of B-12 according to the instruction of my doc. I used to take monthly B-12 shots, but she read in a journal high doses orally can work & I've been tested & my levels are normal. I drink coffee (about 2-3) cups in the morning & take one of my B-12 pills then. The other I take at night. Coffee doesn't seem to be hurting the absorption for me.--Suzy