Lack of motivation to do even the most basic things.

The world starts seeming like a surreal, malevolent place.

Isolating myself to the point of painful loneliness.

Not tending to relationships or having depressive symptoms cause problems, thus increasing my isolation.

Hopelessness.

Watching a great deal of time go by that I can't get back.

Feeling of just existing and not really living.

My mind is sludgy and I can't think well.

Feeling like a klutz at communicating.

Sense of humor goes.

Sleep is hard to come by and lack of it adds to my fatigue and slowed thinking.

Can't enjoy things I love.

Unrealistic guilt and self-flagellation.

Realistic guilt at not getting things done, but still putting them off.

Feeling/being irritable.

Frustration with all of the above and at not being able to make the depression go away.