Well I've been told that vitamin B-12 is really helpful, though I haven't tried it myself yet. We do have St. John's Wart in 300 mg capsules, and my roommate has taken them on a regular basis before. He says that sometimes they do help to easy his depression, however sometimes they don't seem to do a thing. I've only just started taking them and as of yet have seen no difference, however I have this page on my bookmarks bar and if I notice a difference I'll give you another reply. :3 Good luck~