I'm taking it with an ounce or so of cheese, which is fatty. I can't eat late at night---not 500 calories worth anyway, or I'd gain back the 43 lbs. I've lost in two shakes of a lamb's tail. But even that doesn't matter because I'm still full from dinner and can't eat when I'm not hungry. So I make do with the cheese, or sometimes I alternate with a spoonful of Peanut butter.