I would say seroquel makes you waaaaay more tired/zombified. You're on 300mgs, i'm on 900mgs which is why i'm experiencing the fatigue and you're not. You also gotta take into account body weight/height. I'm just 5'2" at 150lbs. But also keep in mind that not everyone will experience the same side effects. Everybody's chemistry is different. Also, i'm told that this side effect subsides with time. Also, your doc can prescribe something to counteract that side effect. He put me on lamictal and is starting to increase it which will give me more of a boost. Also, just read that this guy didn't feel the fatigue effects when his dose was lowered to 600mgs.

That being said...as sucky as the whole trial and error thing is, it's better than the state i was just a month ago. Lithium really worked for me and was fast acting when nothing else was. So, as sick as i am of meds, i'd rather be dealing with this than crying every 5 min with a knife at my wrist. Don't go off your meds because it's a lot easier to "deal" with this stuff with meds than without them. Hang in there. Keep us posted on your updates with lithium. We can compare notes.