I've taken it for 7 years (approximately). It wasn't hte first AP I took, that slowed me down mentally , but then I adjusted and that went away.

I've gained weight since I've been on it - about 60 lbs or so. But it recently stopped, my pdoc said that some people gain only a certain amount, some people don't gain, and some keep gaining weight no matter what.

I take 200 mg and I recently went up to 300 and it wasn't beneficial - I gained weight quickly (about 9 lbs in 1 month) and was extremely tired and had brain fog so we quit that.