I've been on 50 mg. of zoloft for a week and I'm still jittery, especially in the morning and early afternoon. I'm also tired from it, but am not sure if I want to try switching to the mornings. I'm afraid I'll be MORE tired. I've gone so gradually up to 50 mg, from 25 to 37 1/2 and now to 50, over about 7 weeks, that I wonder if zoloft just isn't the med for me. The pdoc just says "you have to get over the hump". Or, he wants to give me something for the "anxiety". But I feel jittery, NOT anxious. I see him in a week so I'll see how I feel. I really thought I would start to feel better on zoloft, instead of this jittery feeling. I hate to think I "wasted 7 weeks" but I know it's all trial and error, this med stuff. What does anyone suggest? Thanks very much.