Antidepressants never worked for me, I tried quite a few and none of them worked so I completely lost hope. Eventually I got diagnosed with bipolar disorder, which seems to explain why the antidepressants didn't work. The chemical imbalances I was going through were very complex. The bipolar medications I've been prescribed are an absolute godsend after all the failed medications. My life is livable again.
Bottomline, there are thousands of medications and infinite medication combinations out there, and one of them is bound to work for you. You've only tried one med, you have to keep trying until you find the medication (or possibly medication combination) that works for you.
I also recommend therapy as well. If you have a good therapist, that can make things so much better.
If the meds and therapy don't seem to work, you have to keep going, even if you have to change your therapist or whatever you have to do. It may take a while to reach the best fit for you, but just have faith and keep going. It's out there somewhere.