They can definitely work if you find the one that is right for you. That can be the hard part, though. It took me years to find one that was good for me. And even so, I still have episodes, and they will probably have to increase the dosage. The problem I've had is that the ones I've used in the past have had to have the dosages increased, and then they poop out. Fluoxetine did that to me. Buspar, Paxil, Effexor, and Zoloft are just some of the ones that have eventually stopped working for me. I'm on Wellbutrin right now, and it's good, but they will have to increase it because the episodes are getting worse. I was thinking, if this one poops out, maybe trying Cymbalta. Maybe Wellbutrin really isn't the perfect one, but it's sure better than the others. Effexor was horrible. It made me an aggressive witch, I couldn't stand being around myself. It also took away my sex drive completely. Just talk to your doctor and maybe they can get you set up on something else. Wellbutrin has worked pretty well for me so far, and it also helps with my ADD. Cymbalta is good for depression, anxiety and fibromyalgia, of which I have all three. Buspar, when I first took it, gave me full-body tremors. But those subsided. Your doc might better be able to help you find one that's right for you. I take another one, clomipramine, for OCD and depression, and I can tell you one thing, that one is a godsend. Most amazing OCD drug that I've ever taken.