I have tried 8 different meds for ADHD-combined type, including Adderall, Focalin, Stratera, guanfacine, Vyvanse, Ritalin (short and long acting), and Concerta. I also just started Zoloft 25 mg for anxiety and depression.

I'm taking that with Concerta 27 mg. I also have a mild case of Tourette sydrome, so most of the stimulants I tried left me twitching uncontrollably for an hour or so. FINALLY--after two years--I sort of figured it out. I was on Concerta 18 mg because 27 was too high, but then I had to augment with short-acting methylphenidate, and now I'm at 27. It's not perfect, and sometimes the side effects suck (ears ringing), but it helps me focus and be a little less fidgety.

As for the Zoloft, I think it might be making me more depressed, or maybe that's just me :/.

Point is, keep trying. It's actually kind of a reckless thing to do because I keep trying something new, so in a way, it is pleasurable. I guess it's all how you look at it.... I try to see one thing with a "glass half full" lens a day, no matter how I'm feeling. Not easy, but there you have it. Good luck!