I tried it. Don't know if I was on the proper dose or if it was a good brand or what not. Took it for maybe two months. Didn't do anything except give me some gastrointestinal upset.

If you do take it, make sure it's a good brand that's been standardized for hypericin and hyperforin content. Kelly's SJW (St. John's Wort) pages for depression is a good website to consult.

Also, it is natural, but it works by tweaking neurotransmitter uptake. It can also make you photosensitive. And never take it with antidepressants or certain other drugs. Natural doesn't mean no side-effects or adverse reactions.