I hate bring old threads back to life but! There is a blood test that will tell if you are lacking folate in your brain. If you have this, the folic acid can't pass through the brain blood barrier but by breaking it down to the L-Methylfolate that can pass thru. thats how my psch. DR explaind it to me. And my blood test show it should work for me, and boy does it. DR switched me to Prestiq 50mg from 200mg Zoloft. Throw in the 15 mg Deplin and I am almost too happy with tons of energy, any more and I think it would be manic. Going to to talk to the DR tomorrow about splitting the deplin in half as the Prestiq is time release and can't be split. Would just like to tone it down a bit. Has anyone split there Deplin in half and is it ok before I ask DR.