Crashed Again is right on the money! Before you know whether or not to try it, the blood test is critical. I know I'm not going to say this correctly, but here's the gist of it, from what I could understand. Maybe one of the mods can fill in the gap. The test my psychiatrist ordered for me actually looks to see if your DNA is "mutated". There are varying degrees, which he went into detail with me. If there is no mutation (I HATE that word LOL) or if there is only 1 abnormality, the Deplin is not likely to help. If you have 2 or more ( I had 2 ), the Deplin could make a significant improvement in your seratonin, dopamine, and norepinephrine levels. I WISH I could tell you how it's working, but I just got the prescription on Friday. Because the cost is MUCH cheaper using mail order ($100 for a 90 day supply) thru my insurance, it will be a few days before I have any results. I'll be glad to share them when I do!