LookN4Answers, you remembered that DNA gobbly gook better than I did and yeh I have 2 screwed up receptors also. I have only been taking it since 2/7/13. I could feel it after I think 5 days. My Psch DR said it takes 4 to 6 weeks to completly get into your system, thats where I am now. I sure like the energy and feeling of well being as it sure beats the alturnative. I would just like to tone it down just a very small touch. I will ask my DR on tuesday about that splitting the Deplin. As good as I feel now, I'm not doing anything with out the docs approval. I pray that it works as good for you as it is for me. I know its costly but as good as it works for me I would, heaven forbid pay twice what it cost. Splitting those 90 pills would sure save abunch of money though.