Well, it's no wonder you feel terrible. The list of negative stuff going on around you would make anyone feel terrible.

Your T left so do you have a way of finding a new T? I know it can be hard to find a new one that you feel comfortable with sometimes. Do you have a pdoc? Sometimes giving warning to the doctor about what's going on can help on a medication level, since you're already on meds.

Do you have any strategies that you learned from your old T for coping skills? Sometimes using what you learned can be helpful even if you're on your own. Or you can try meditation, see if you can calm the mind a bit. Also make sure you're eating right or as close as possible. Try going to bed at the same time even if you just lay there. Try to get into a routine, the bipolar brain loves a good routine.

Those are my only suggestions. I'm guessing there is some tension with your sister. Does she support you when it comes to bipolar? Maybe let her know you're not doing so well if she does.