I started feeling better around 75 mg, and a lot better at 125. I had a brief manic episode when I hit 150, but that effect went away at 200. Now I'm on 250 and I think that's about the right amount, because I'm pretty stable (although I'm also on an AD and an AP as well as a benzo, so I'd BETTER be!) and I'm not having any side effects that I'm aware of.