Depression and BP for me is one bad cycle that doesn't end. Like an emotional rollercoaster. I've been on SSRIs, MAOs, older anti-depressants plus ECT. Been on effexor (75 mg w/no side-effects) for 6 yrs and it keeps me from dipping really low. My PDOC told me it's one AD that works completely differently at higher doses: It changes which neurotransmitters it works on. At 75 mg it works on one neurotransmitter, at 150 mg it works on two completely different neurotransmitters.