I believe that I started feeling an effect within the first week or so, but this effect was very subtle -- my thoughts were calmed down instead of 'garbled' and 'static-y' and I began to sleep better. As the dose goes the benefits were more pronounced, but it took me a few months to get to 200mg because of the slow titration. 200mg is generally The Dose that seems to do the trick. However, I have learned that it is not enough and I may begin taking something else with it.