I gained 30+ pounds almost immediately after I was put on Seroquel. It was devastating because I've always been on the low side of normal in my weight range. Seroquel and some other anti-psychotics completely shut down metabolism. In most cases, diet and exercise won't help. The weight started coming off as my dosage decreased. (Carrots took care of the rest. ) I haven't weighed myself in three years. I couldn't handle the numbers. I can tell what I need to know by the fit of my clothes.