Yeh if the blood test don't show that what ever it is that is suppost to be mutated isn't it won't do anything. Its a DNA thing. my test show 2 mutants, the Deplin Pharma co. said that it is more uncommon to have 2 mutations when I talked to them on the phone, that is probably why my mood and energy when to the moon. Deplin also does not work by its self, needs an AD med.