Re: meds "pooping out". Not all depression is due to low serotonin. If you're taking an SSRI and it works for a while, then "poops out", it's likely that you are having depressive symptoms due to a different chemical issue than serotonin. For example, low norepinephrine or low dopamine. It's not so much that the med poops out, but rather that it no longer is the appropriate one to use.