I tried the non-ER as well. The problem was that I'd have to take it within an hour of going to bed because the instant release hit me like a rock. I'm a night owl by nature and don't always go to bed at the same time. If I took it too late I'd have a really hard time getting up because it hadn't worn off.

Seroquel is a strange drug for me. It got me out of a really deep depression, but at a high cost.