For most people, Seroquel shuts down metabolism while creating monster carbohydrate cravings. The usual route of diet and exercise doesn't work. Seroquel is well-known to cause weight gain and because of that many doctors (mine included) try to prescribe weight-neutral meds before they have to resort to it. I've always been thin. When I was put on 300 mgs of it I gained 30+ pounds. When my dosage was decreased to 25 mgs, the weight came off. This is my experience only but I'm compelled to share it. It's not always about "stuffing your face" or taking "responsibility for your choices."