Hmm. I have hypothyroidism and am Bipolar, but I don't know what might be going on with the tiredness and the weight gain. It could be associated with your meds and with depression.

I suggest you contact your doctor as soon as you can when the office is open. I'm like you, I can't imagine your thyroid condition might change this fast, but I just don't know.

I hope things will be better soon!