I have Bipolar 1 disorder. I've been taking Seroquel and Lamictal for about three years. Several months back I found myself sinking into depression. My first depression had very serious consequences. It's true there is a risk of becoming manic after going on an antidepressant, but it was a risk I was willing to take. Pdoc was totally onboard. I went on Effexor because I've taken it in the past with success and I believe it's helping me now. I don't know for certain that there is a different risk factor for BP2 as opposed to BP1 but I would think so. BP2 doesn't exhibit mania to begin with.