I've been on Lexapro for almost 2 years straight with literally no side effects ever! No nausea, no fatigue, no extra anxiety/depression, no weight gain or appetite change, no headaches...NOTHING! It has been extremely effective until recently, and has now seemed to have pooped out on me, so my pdoc is switching me to something else (Viibryd). But for the time it worked, I absolutely LOVED it!!