I stayed on zyprexa and gained 10-15 lbs over 3 months. I had my pdoc discontinue the medication and have stayed at a relative weight since. (I haven't really been able to lose zyprexa weight, but my BMI is something like 21.5)

I take seroquel now, which is known for weight gain, but haven't experienced any. I try to drink at least 32 oz. of water/liquid without high frutose corn syrup/sugar a day, if not more. I believe drinking more water has actually helped me maintain weight and not gain any more, even on a drug like seroquel.

I agree with Venus though. You don't have to be "fat and happy". I know I didn't tolerate it and switched meds for that reason.