my T and pdoc think I just need to see if it gets better with my new meds. I don't know how long it takes Seroquel to reach full effectiveness but I hate it right now. Weight gain has me obsessing over food and appearance like I never did before. Sure it keeps me out of really bad depression, for the most part, but it just made my originally pretty tame and few and far between hypomanic episodes both much more common and a lot worse. And now I'm just grouchy and in pain.