Do we have depression initially because we believe a part of us is missing. Or in other words we put a substance in us and now that we do not have it we are suffering from withdrawal or discontinuation syndrome. In this way we now have an addiction. If you put the substance back in you will have the same cycle of addiction. The withdrawal effect is depression. Now we need to replace the substance with something else. When it feels like a part of us is missing, an illusion that we are not whole persons. We are unconscious that we are not complete without the substance so we may react and begin to hate ourselves. When we feel complete we love ourselves again.