Maus, it's the genetic re-engineering of wheat (during the 50's and 60's, I think) that has altered the health value of that grain.

The problems are centered in the breakdown of gluten in which particles called "exorphins" act on the opiate centers of the brain and other parts of the body
where opiate receptors are located. Exorphins can cause everthing from acne to
dementia, according to Dr. Williams.