I can sort of relate to the anger part. My anger/irritability is not because I am truly angry though. Just the way I have been conditioned over the years from my undiagnosed ADD. But not taking it for a day or two I can see how that could possibly contribute to making you more angry/irritable if your body is use to it. Although for me. The XR made me Irritable while taking it as well. So I stopped that med. The depression can also be a side effect of not taking the med for a few days. That is why the doctors taper you down slowly typically when they are weening you off the medication. I would try to talk to y our doctor about the symptoms you have described in your posts here as well. Sounds like the adderall does help you. What time do you take your adderall XR typically? Does it ever seem like it effects your sleep pattern?