When you are ready.
You will know that you are ready because your mind, body and spirit will be in agreement with the "yes".

If there is any doubt, its a flat out "no".
Also I want to echo Roman and Harley's posts...

Your choice of words speak volumes and in response to that, I would just like to present the following question to you:

"Give in" is tantamount to being defeated, why are you so very interested in being defeated?