I suffer from chronic depression as well. I also get tired of going back to work Monday mornings...mostly because over the weekend all the work will pile up and by Monday it really seems overwhelnming. I think at least some of my depression must be chemically related. I already have problems balancing out my hormones, and that must affect my other chemical receptors as well. Medication (now that I found the right mixure/doses) has made coping with these issues much easier. I wouldn't say I am at a 10 out of ten, but I definitely went from a 4 to an 8 on my normality meter.