I just checked online for ketamine use in medication-resistant depression. It's much improved over the years and doctors are getting good results.

There is a Ketamine clinic at Drexel University in Philadelphia. Dr. Schwartzman is in charge, and a contact doctor named Dr. Getson may be reached at 586-983-7246. They have in-patient and out-patient treatment scheduling.
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I would add to my statement about Deplin that research indicates 70% of depressed patients are lacking in the ability to convert folic acid into folate because of missing enzymes in patients. Genetic testing is the prescrbed way to go, but it can be used as an adjunct to prescribed meds and is not harmful. In fact, it's called a "med food" (about $20. per month and requires a med prescription).