I learned a long time ago to check the side effects of a medicine. If a side effect is depression or anxiety, I can't take it. It makes the depression/anxiety I already have to go completely out of control. Grapefruit is a gigantic culprit of a food you can't take with a lot of meds. It, with a number of meds, causes extreme anxiety, and if you're already prone to it, you could find yourself if a heap of trouble.