hi jonb,
i have been taking topamax for almost five years now. i started at the low dose of 50 mg for migraine prevention (which it works very well for ME for THAT), but am now up to 100 mg AM & 200 mg PM daily for mood stabilization. i have lost some weight on this medication, but not a substantial amount, and it has been over quite some time. BUT, from what i understand, it is different for each person. i have noticed my sense of smell is a bit different and my body odor has seemed to change (in what seems to ME an offensive way). as for the brain fog... it has gotten much worse for me at the higher dosage. so much so that i had to drop out of school. i seem to lose words during conversations that have been in my vocabulary for years, only for them to reappear when i don't need them. terribly frustrating and embarrassing for me, to say the least. unfortunately, topamax helps me so much with my moods that i dare not discontinue it. sure hope this helps you! dawn