I would visit the area where you would be living and even interview for the position. It doesn't hurt to look.

This is more a question of where you want to be in your life right now. Are you looking forward to being more settled, or do you still want to have adventures and live abroad? If things looked good overseas then I would be tempted to take a chance.

How risk averse are you? It would be more expensive and you would be paid less. There's also a good chance that it would not be a wonderful experience and you would want to leave after a time. At that point you might be able to move back to the US and get a job in a nicer climate.

Just how much do you like your job? Enough to stay in a place you dislike? That's what it really comes down to. If you're going to leave eventually then I wouldn't let it hold you down.