Would it be possible to turn the joke around on them so they feel stupid?

I don't know, I don't want to say anything offensive, so accept my apology in advance if this is....

But think up responses to their most frequent stupid comments, like, idk...

Other guy: "Look what the cat dragged in!"

You: "No doubt! I can barely move after last night's f**k-a-thon! By the way, your mom says hi."

Or

They act like you are gay....

So behave in a stereotypical, exaggerated gay manner. Put a vase of flowers on your desk, and a copy of Cosmo. When someone bends over, etc, make a point of pretending to look....and make sure they see you. Then, smile and wave.

Go on their Facebook, and find a picture of their sister, mom, or grandma. Buy a heart shaped frame, print out the picture and place it in the frame. Set it on your desk. Refuse to mention.

Try to set it up so some old friend you haven't seen in ages stops to visit. Be sure your friend mentions a lot of interesting things, like how you graduated summa cum laude from Harvard, got drunk that time and beat up all those guys trying to gang rape a lady with your mad karate skills, have a General Lee car you only drive on special occasions, used to ride bulls in the rodeo, and won an Oscar for your part in a porno movie. Cause of your...you know....HUGE...you know. Lol.

Anything to make them either leave you alone due to sheer annoyance, jealousy, or finally actually realizing they aren't in high school anymore and they are acting like dicks.

Obviously if that would get you in trouble, don't....but if it wouldn't....it would be funny....and they'd look stupid.

Otherwise, I would say to start seeking a new, friendlier work environment. You had something going for you, or they would never have hired you. Polish up your resume and seek a place where you are given respect, as you deserve.