I have been on Zoloft, Prozac, Lithium, Ritalin, Wellbutrin, Paxil, Lexapro, effexor, Pristiq, Provigil, Ambilify, trazodone. None worked. Some in fact made me much worse. I am on Lamictal and cymbalta right now with Ativan. It worked to keep me stable for 3 years but now it is as if it stopped working and I am having a bad depression now. Just went through a trail of abilify that made me worse and then Pristiq that made me worse. The only thing I have not tried is a maoi like the Ensam patch. My doctor seems hesitant to put me on that because I would have to do a wash out of my antidepressant cymbalta for 2 weeks and the depression could get worse, but I feel like I need to try whatever I can. I am just praying I find the right drug or right combination. My quality of life is so diminished.