Prozac felt for a while like "a dark cloud of gloom had lifted" sort of, but it pooped out eventually and I really disliked the side effects (nausea, much greater need for sleep, sexual side effects). Wellbutrin just turned me extremely impatient and irritable. Remeron was great as an anti-anxiety med but gave me horrible nightmares and pretty much deleted my personality after a while (worst med ever!!!). I no longer take any of them. Prozac was the most benign of the three for me. I don't have much luck with meds.