I am on 600mg of Seroquel IR. I have been on Seroquel for over a year. Yes you do get the munchies, but if you don't over eat, you don't gain weight. I dont even get the munchies anymore. Actually Seroquel looses the sedative effect after 400mg and the anti-psychotic features are stronger above 400mg. So essentially, 300mg is more sedating than 600mg, go figure. This is what my doctor and I got in a conversation about. Just my 2 cents. 1000mg is a large dose though. Must have some hefty hallucinations to be on that much.