Sorry this has happened to you.

Regardless of her being bipolar, on meds or off meds. Someone with Bipolar can take there meds and do everything possible to avoid a manic or depressive episode and they can and will still happen at times.

Your wife has to want to repair the marriage.

Maybe you should talk to a therapist, just about what you are going through, Your therapy shouldn't be about "fixing "her.. Just about can you / will you / do you want try and salvage your marriage?

You are in a tough place, I hope your able to find what direction you should take for you and your children.

Good luck