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Originally Posted by George H.
 I'm a George  Some very interesting and thoughtful replies here. Mine is simple... we are a collection of chemicals acting and reacting so yeah when something isn't working it has to be chemically related. IT, your seratonin is a chemical and your brain is just a chemical reaction machine.
Synapses firing? Electricity through chemical reactions.
I'm not sure it's an "either or" question. I don't think researchers or doctors are even close to knowing what is going on here... but I believe chemical imbalance is just a hypothesis. It may be a good one but saying it's a chemical imbalance is not much better than saying I think I sort of understand part of the problem but not how or why it has the effect that it does.
If that doesn't make sense don't blame me... it shouldn't make sense and I think doctors who want us to believe they have it figured out are not just wrong... they are incredibly arrogant
I don't think doctors even understand why cancers form from previously normal cells so I'm not surprised that they haven't figured out how some minds go haywire or how to fix them.
I just read about a study that compared the effectiveness of St Johns wort, Zoloft, and a placebo in treating depression.
The St John's wort had a 24% success rate. Zoloft was 25%. The placebo had a 32% success rate... and it's much cheaper 
me when I read this post tomorrow --->  
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I agree with George. Our thoughts and emotions all come from the brain. The brain is so complex and there are so many things that can go wrong with it. No one really understands it (yet?). But I think when they say "chemical imbalance" it is a vague catch all phrase that means "somethings wrong, don't exactly know what."