Hi, for the past several years I have been stable on lamictal and cymbalta for my bipolar. I am writing in the depression section because I have only had one manic episode in my life. It just seems I have recurring major depression to me, but that was my diagnosis. I have been in a depression since December. It was as if my meds just stopped working. I toughed it out until February when I called my doctor and he put me on abilify in addition to the other 2 meds. When that didn't work he put me on Pristiq. When that didn't work he put me on Adderall. When that didn't work he doubled my lamictal. Now that is not working and I am more than frustrated. I have an appointment this week but I don't know if I can take one more med change. I have gotten more and more depressed over these months of trying all these meds and failing. I know I have to do something and I have to keep trying but nothing is working Also in the past I have been on prozac, zoloft, paxil, wellbutrin, effexor, lexapro, etc. and more. No success. Can anyone offer any suggestions? The only thing I have not tried is a MAOI and I think that is the next thing my doctor will put me on. Sorry for the long post thanks for reading, just frustrated here!