I have been on ambien alone then with several different benzos and opiates. Right now I am on it with antipsychotics. I have not had an unusual time really, you have to expect it to be a bit stronger on an antipsychotic, I have never had to really rehab off ambien just endur 3 sleepless nights while it gets out of my system. All the others, benzos, opiates. and antipsychitocs take weaning and time to get off off