Effexor XR, Lexapro then Zoloft. Even though I don't think it was because of the medication they still had to make me change what I was taking due to suicide attempts while on the first two. I really don't remeber how Effexor or Lexapro affected me since I was on them for such a short amount of time before it got changed to something else. Zoloft actually started to help a lot until I got to the point where I had no emotions, couldn't sleep, and had some other things that were going on as well, I'm going to give it one more chance though since it did help atleast most of the year I was on it, I don't know if it wore out or what I guess I'll see what happens when I start again