I can relate to almost everything you talk about. I also lack the know how to make friends. I've never been able to make them or to keep them if I did make them.
The best thing I've found for that loneliness and alienation is to help others. Find some way to give love and support to someone. There are so many groups that focus on helping others that it is relatively easy to find somewhere that fits your personality. Even if you don't get the acknowledgement you would hope for from these actions the benefit is enormous.
Keep trying with the meds. They are discovering new things all the time. It took 2 years to get the right mix.
I hope you feel better soon.You definitely came to the right place!