I'm having problems right now with my meds crashing on me in the late afternoon. I get up early, but have tried putting off taking the meds to see if they will last longer; but, nope, about 1500 I take a nose dive. I talked to my dr. about this as I'm trying to get him to add a stim to my plethora of meds (fat chance) and he has me taking my meds in sections instead of all at once. It's not working either. Then once I crash, my mind turns to the things that hurt the most and ssllliiddeeee right into a major depression. There has got to be a way. (changing meds is not an option; I've tried almost all of them and Parnate (an MAOI) is the ONLY one that works for me. Hope you are feeling better.