I take 600 mg of Seroquel at bed time. When I first started taking it, 6 years ago, it knocked me unconscious practically. However, I was so delusional and hallucinating while manic my psychiatrist really wanted me to stick with it. Anyway, 6 years later, it does not affect my sleep at all now but it is good for my psychotic symptoms. Be patient. New drugs take time to adjust to.